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KMID : 0366919920040010019
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Sungkyun Pharmceutical Journal
1992 Volume.4 No. 1 p.19 ~ p.23
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A Study on the Synthesis of N-p-Hydroxybenzoyl-5-Hydroxy Anthranilic Acid Derivatives
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Abstract
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melandrin, as a possible phytoalexin, which is expected to have the various pharmacological activities; antibacterial, antifungal and antiviral activity, was isolated in 1987 by Woo from Melandrin firmum (Caryophvllacease). The synthesis of
melandrin
derivatives has bene accomplished by the reaction of 5-hydroxy anthranilic acid ethyl ester with acid chlorides and then by hydrolysis of ethyl ester.
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